Devices·Jul 12, 2026
A device is only as good as the protocol the operator runs on it. These are the working parameters we've refined across 350+ DRS-supported clinics for the most commonly requested fractional dermal infusion indications.
Universal parameters
- Needle depth: 0.25–1.5 mm depending on region and indication.
- Vacuum: 0.3–0.6 bar. Lower for thin skin, higher for scarred tissue.
- Passes per zone: 4–6 in overlapping vectors.
- Cadence: 2–4 weeks between sessions; series of 3–6.
- Session length: 30–60 minutes.
Global facial rejuvenation
- Depth: 0.5 mm cheeks / temples; 0.25 mm eyelids and perioral.
- Vacuum: 0.4 bar.
- Formulation: non-cross-linked HA + polynucleotides; or PRP prepared from a 15 mL draw concentrated 5–7×.
- Series: 4 sessions, 3 weeks apart, then quarterly maintenance.
Melasma and pigment irregularity
- Depth: 0.25–0.5 mm — go conservative; deeper channels risk PIH.
- Vacuum: 0.3–0.4 bar.
- Formulation: tranexamic acid + azelaic + niacinamide serum, plus HA vehicle.
- Series: 4 sessions at 4-week intervals with strict photoprotection.
- Do not treat over active inflammation or during pregnancy.
Acne scar remodeling
- Depth: 1.0–1.5 mm over rolling/boxcar scars.
- Vacuum: 0.5–0.6 bar for enhanced infiltration into fibrotic tracts.
- Formulation: PRP-PRFM as primary; add exosome serum in resistant cases.
- Adjunct: subcision of tethered scars 2 weeks pre-infusion; RF-microneedling in alternating sessions.
- Series: 6 sessions at 4-week intervals; expect 40–60% improvement on Goodman scale.
Androgenic alopecia (scalp protocol)
- Depth: 1.0–1.5 mm over vertex and frontal zones.
- Vacuum: 0.4 bar.
- Formulation: PRP concentrated 6× + copper peptide serum + exosome serum.
- Series: monthly ×4, then every 2–3 months for 12 months.
- Pair with topical minoxidil and, where appropriate, oral 5α-reductase inhibitor.
Neck, décolleté, hands
- Depth: 0.5–0.75 mm.
- Vacuum: 0.3–0.4 bar.
- Formulation: HA + antioxidant serum; PRP quarterly for structural effect.
- Series: monthly ×4, then quarterly.
Post-laser and post-microneedling recovery
- Depth: 0.25–0.5 mm.
- Formulation: amniotic flowable matrix or exosome serum — supports epithelial recovery and reduces PIH risk.
- Timing: within 4 hours of the primary procedure while channels remain open.
Sequencing and combination therapy
- Same-day pairing: laser first, dermal infusion second — the laser creates the open channels the serum needs.
- Alternating sessions: dermal infusion + RF-microneedling on alternating months balances biology and thermal remodeling.
- Injectable pairing: avoid over injected filler sites for 2 weeks post-filler to prevent displacement.
Contraindications and precautions
- Active infection or open acne cyst in the treatment field.
- Isotretinoin within the past 6 months (relative — some 2025 data supports safety).
- Uncontrolled bleeding disorder or therapeutic anticoagulation.
- History of keloid formation — perform a small test area first.
Outcome tracking
Standardize a photo protocol (fixed light, distance, angle) and re-image at each session plus 12 weeks post-series. Global Aesthetic Improvement Scale (GAIS) at 4 and 12 weeks; FACE-Q patient-reported outcome for skin quality. Practices that document outcomes convert consult-to-package at 2–3× the rate of practices that don't.