What are Amniotic Products?
Amniotic products are derived from the amniotic membrane – commonly referred to as Amnion and Extracellular Matrix (ECM) – and amniotic fluid that are donated after the delivery of a healthy baby. They can contain as many as 250X the growth factors of PRP/PRFM. Amniotic products are anti-inflammatory by nature, therefore amniotic fluid helps reduce inflammation, increased epithelial cell reproduction, and increases angiogenesis. Amnion/ECM is particularly powerful in orthopedic and aesthetic applications due to the preponderance of growth factors and proteins organized and supported by a cellular matrix which serves to support the regeneration of healthy tissue.
Amniotic fluid is the protective liquid contained by the amniotic membrane that serves as a cushion for the growing fetus and to facilitate the exchange of nutrients, water, and biochemical products between mother and fetus. Amniotic fluid contains a substantial number of growth factors and immune components. Purified amniotic fluid has had extraneous cells removed but is then immediately frozen to preserve the potency of its growth factors and nucleic acids. Because there are no cells and therefore no need to include a diluting cryopreservant, purified amniotic fluid is able to deliver twice the number of factors (anti-bacterial defensins, anti-inflammatory cytokines and neo-natal growth factors) as offered in standard amniotic products.
Amnion / Extracellular Matrix (ECM)
Amniotic membrane, or amnion, is the innermost layer of the placenta and consists of a thick basement membrane and an avascular stromal matrix. Amniotic tissue has a series of anti-inflammatory, anti-bacterial, anti-viral properties as well as low immunogenicity. Clinicians have used Amnion for over a century as a biologic dressing in a broad range of therapeutic applications.
Amnion/ECM has been generally recognized and used as versatile wound coverings, with published clinical results cited extensively in literature. Amnion is an abundant source of collagen, as well as other proteins and cytokines. The collagens in amnion provide a structural tissue matrix for cellular attachment. While providing structural support to cells, the extracellular matrix assists in the migration and proliferation of the patient’s own cells to the site of injury or defect.
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