Publications and Research

Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis.
Mykoniatis I, Pyrgidis N, Sokolakis I, Ouranidis A, et al. JAMA Netw Open. 2021 Feb 1;4(2):e2036337. doi: 10.1001/jamanetworkopen. 2020.36337.

Erectile Dysfunction Treatment Using Stem Cells: A Review.
Protogerou V, Chrysikos D, Karampelias V, Spanidis Y, Sara EB, Troupis T.Medicines (Basel). 2021 Jan 6;8(1):2.

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General

    1. 2021 Mar 06Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review.
      Mostaghimi A, Napatalung L, Sikirica V, et al. Dermatol Ther (Heidelb). doi: 10.1007/s13555-021-00512-0.
    2. 2021 Mar 03 – Modern management of genitourinary syndrome of menopause.
      Da Silva AS, Baines G, Araklitis G, et al. Fac Rev. 10:25. doi: 10.12703/r/10-25.
    3. 2021 Feb 26The Potential Relevance of the Microbiome to Hair Physiology and Regeneration: The Emerging Role of Metagenomics.
      Constantinou A, Kanti V, Polak-Witka K, Blume-Peytavi U, Spyrou GM, Vogt A. Biomedicines. 9(3):236. doi: 10.3390/biomedicines9030236.
    4. 2021 Feb 1 – Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis.
      Mykoniatis I, Pyrgidis N, Sokolakis I, et al. JAMA Netw Open 4(2):e2036337. doi: 10.1001/jamanetworkopen.2020.36337.
    5. 2021 Jan 9 – Alternative Treatment for Erectile Dysfunction: a Growing Arsenal in Men’s Health
      Wade Muncey, Nicholas Sellke, Tyler Kim, et al. Curr Urol Rep. 22(2):11.
    6. 2020 Sept 26 – Exercise and Quality of Life in Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
      Nguyen TM, Do TTT, Tran TN, Kim JH. Int J Environ Res Public Health. 17(19):7049. doi: 10.3390/ijerph17197049.
    7. 2020 Jul 2 – The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta-analysis.
      Zhou Y, Chen C, Qu Q, Zhang C, Wang J, Fan Z, Miao Y, Hu Z. Dermatol Ther. 33(4):e13741. doi: 10.1111/dth.13741. Epub 2020 Jul 2. PMID: 32478968.
    8. 2020 May 19 – Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction
      Ming-Che Liu, Meng-Lin Chang, Ya-Chun Wang, et al. Cells. 2020 May; 9(5): 1250.
    9. 2020 Apr 13 – Efficacy of non-surgical treatments for androgenetic alopecia in men and women: a systematic review with network meta-analyses, and an assessment of evidence quality.
      Gupta AK, Bamimore MA, Foley KA. J Dermatolog Treat. 1-11. doi: 10.1080/09546634.2020.1749547. Epub ahead of print. PMID: 32250713.
    10. 2020 Mar 12 – Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms.
      Houschyar KS, Borrelli MR, Tapking C, Popp D, et al. Dermatology. 236(4):271-280. doi: 10.1159/000506155.
    11. 2020 Jan 1 – Incorporating Aesthetic Devices into a Dermatologic Practice
      Jusleen Ahluwalia, Chloe Gianastano, Jill S Waibel. J Clin Aesthet Dermatol. 13(1):18-21.
    12. 2019 Aug 26 – A Systematic Review of Outcomes and Patient Satisfaction Following Surgical and Non-surgical Treatments for Hair Loss.
      Rosati P, Barone M, Alessandri Bonetti M, Giorgino R, Panasiti V, Coppola R, Tambone V, Persichetti P. Aesthetic Plast Surg. 43(6):1523-1535. doi: 10.1007/s00266-019-01480-9.
    13. 2018 Jul 01 – Penile vibratory stimulation in penile rehabilitation after radical prostatectomy: a randomized, controlled trial.
      Clavell Hernandez J, Wu Q, Zhou X, et al. J Sex Med. 2018;15:S253–4.
    14. 2018 Jun 17 – Review and clinical experience exploring evidence, clinical efficacy, and safety regarding nonsurgical treatment of feminine rejuvenation.
      Gold M, Andriessen A, Bader A, Alinsod R, French ES, et al. J Cosmet Dermatol. 17(3):289-297. doi: 10.1111/jocd.12524.
    15. 2017 Jul 21 – Vaginal rejuvenation: current perspectives.
      Barbara G, Facchin F, Buggio L, Alberico D, Frattaruolo MP, Kustermann A. Int J Womens Health 9:513–519
    16. 2016 Jul 26 – Genitourinary syndrome of menopause: An overview of clinical manifestations, pathophysiology, etiology, evaluation, and management.
      Gandhi J, Chen A, Dagur G, Suh Y, Smith N, et al. Am J Obstet Gynecol 215: 704-711.
    17. 15 Oct 19 – Intracavernosal injection for the diagnosis, evaluation, and treatment of erectile dysfunction: a review.Belew D, Klaassen Z, Lewis RW. Sex Med Rev. 2015;3:11–23.
    18. Alternative Treatment for Erectile Dysfunction: a Growing Arsenal in Men’s Health
      Wade Muncey, Nicholas Sellke, Tyler Kim, Kirtishri Mishra, Nannan Thirumavalavan, Aram Loeb. Curr Urol Rep. 2021 Jan 9;22(2):11
    19. Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis.
      Mykoniatis I, Pyrgidis N, Sokolakis I, Ouranidis A, et al. JAMA Netw Open. 2021 Feb 1;4(2):e2036337. doi: 10.1001/jamanetworkopen. 2020.36337.
    20. Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction
      Ming-Che Liu, Meng-Lin Chang, Ya-Chun Wang, et al. Cells. 2020 May; 9(5): 1250.
    21. Penile vibratory stimulation in penile rehabilitation after radical prostatectomy: a randomized, controlled trial.
      Clavell Hernandez J, Wu Q, Zhou X, Nguyen JN, Davis JW, Wang R. J Sex Med. 2018;15:S253–4.
    22. Intracavernosal injection for the diagnosis, evaluation, and treatment of erectile dysfunction: a review.
      Belew D, Klaassen Z, Lewis RW. Sex Med Rev. 2015;3:11–23.
    23. New advances in erectile technology.
      Stein MJ, Lin H, Wang R. Ther Adv Urol. 2014;6:15–24.
    24. Penile vibratory stimulation in the recovery of urinary continence and erectile function after nerve-sparing radical prostatectomy: a randomized, controlled trial.
      Fode M, Borre M, Ohl DA, Lichtbach J, Sønksen J. BJU Int. 2014;114:111–7.
    25. Summary of the recommendations on sexual dysfunctions in men. 
      Montorsi F, Adaikan G, Becher E, Giuliano F, Khoury S, Lue TF, et al. J Sex Med. 2010 Nov;7(11):3572-88.
    26. Prevalence and risk factors for erectile dysfunction in the US.
      Selvin E, Burnett AL, Platz EA. Am J Med. 2007;120:151–7.

Extracellular Vesicles / Exosomes

        1. 2021 Feb 25 – Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspectives
          Leila Taghiyar, Shahrbano Jahangir, Mojtaba Khozaei Ravari, et al. Adv Exp Med Biol. doi: 10.1007/5584_2021_625.
        2. 2021 Feb 12 – The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics.
          Xiong M, Zhang Q, Hu W, Zhao C, Lv W, Yi Y, Wang Y, Tang H, Wu M, Wu Y. Pharmacol Res. 2021 Apr;166:105490. doi: 10.1016/j.phrs.2021.105490. PMID: 33582246.
        3. 2021 Feb 12 – Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration
          Shuangpeng Jiang, Guangzhao Tian, Xu Li, et al. Stem Cells Int. 2021:8882505. doi: 10.1155/2021/8882505.
        4. 2021 Jan 27 – The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles
          Margot Jarrige, Elie Frank, Elise Herardot, et al. Cells. 10(2):240. doi: 10.3390/cells10020240.
        5. 2020 Dec 26 – Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
          Alberto González-González, Daniel García-Sánchez, Monica Dotta, et al. World J Stem Cells. 12(12):1529-1552. doi: 10.4252/wjsc.v12.i12.1529.
        6. 2020 Nov 4 – Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study
          Hyuck Hoon Kwon, Steven Hoseong Yang, Joon Lee, et al. Acta Derm Venereol.  100(18):adv00310. doi: 10.2340/00015555-3666.
        7. 2020 Oct 29 – Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis
          Xige Zhao, Yanhong Zhao, Xun Sun, et al. Front Bioeng Biotechnol. 8:575057. doi: 10.3389/fbioe.2020.575057.
        8. 2020 Jul 29 – The Potential of Amniotic Fluid-Derived Extracellular Vesicles to Treat Severe Acute Respiratory Syndrome Coronavirus 2 Infection Versus Hydroxychloroquine in Human Patients. 
          White IA. (2020). Epidemiology OJ.; 5(1):8-12.
        9. 2018 Sep 26 – MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury
          Xi Ouyang, Xiaoyan Han, Zehong Chen, et al. Stem Cell Res Ther. 9(1):246. doi: 10.1186/s13287-018-1003-1.
        10. 2018 Aug 3 – Therapeutic Potential of Human Adipose-Derived Stem Cell Exosomes in Stress Urinary Incontinence – An in Vitro and in Vivo Study
          Jianshu Ni, Hongchao Li, Yiwen Zhou, et al. Cell Physiol Biochem. 2018;48(4):1710-1722. doi: 10.1159/000492298.
        11. 2018 Jul 16 – Exosomes derived from mesenchymal stem cells exert therapeutic effect in a rat model of cavernous nerves injury. Li, M., et al. (2018). Andrology 6(6): 927-935.
        12. 2018 Jan 1 – Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function
          Yin Hu, Shan-Shan Rao, Zhen-Xing Wang, et al. Theranostics. 8(1):169-184. doi: 10.7150/thno.21234.
        13. Exosomes derived from mesenchymal stem cells exert therapeutic effect in a rat model of cavernous nerves injury.
          Li, M., et al. (2018). Andrology 6(6): 927-935.
        14. MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury
          Xi Ouyang 1, Xiaoyan Han 2, Zehong Chen, et al. Stem Cell Res Ther. 2018 Sep 26;9(1):246. doi: 10.1186/s13287-018-1003-1.

Allografts: MSCs and Placental-derived Biologics

        1. Erectile Dysfunction Treatment Using Stem Cells: A Review.
          Protogerou V, Chrysikos D, Karampelias V, Spanidis Y, Sara EB, Troupis T.Medicines (Basel). 2021 Jan 6;8(1):2.
        2. Novel Emerging Therapies for Erectile Dysfunction.
          Kim S, Cho MC, Cho SY, Chung H, Rajasekaran MR.World J Mens Health. 2021 Jan;39(1):48-64.
        3. The good, bad, and the ugly of regenerative therapies for erectile dysfunction.
          Campbell JD, Milenkovic U, Usta MF, Albersen M, Bivalacqua TJ.Transl Androl Urol. 2020 Mar;9 (Suppl 2):S252-S261.
        4. Current status and prospects in the treatment of erectile dysfunction by adipose-derived stem cells in the diabetic animal model.
          Yan H, Ding Y, Lu M. Sex Med Rev. 2020;8:486–91.
        5. The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study-6 Months Results.
          Protogerou V, Beshari SE, Michalopoulos E, Mallis P, Chrysikos D, Samolis AA, Stavropoulos-Giokas C, Troupis T.Medicines (Basel). 2020 Mar 18;7(3):14.
        6. Administration of adipose derived mesenchymal stem cells and platelet lysate in erectile dysfunction: a single center pilot study.
          Protogerou V, Michalopoulos E, Mallis P, Gontika I, Dimou Z, Liakouras C, et al. Bioengineering. 2019;6.
        7. Safety and potential therapeutic effect of two intracavernous autologous bone marrow derived Mesenchymal stem cells injections in diabetic patients with erectile dysfunction: an open label phase I clinical trial.
          Al Demour S, Jafar H, Adwan S, AlSharif A, Alhawari H, Alrabadi A, et al. Urol Int. 2018;101:358–65.
        8. A 12-month follow-up after a single intracavernous injection of autologous adipose-derived regenerative cells in patients with erectile dysfunction following radical prostatectomy: an open-label phase I clinical trial
          Haahr MK, Harken Jensen C, Toyserkani NM, Andersen DC, Damkier P, Sørensen JA, et al. Urology. 2018;121:203.e6–203.e13.

        9. Intracavernous injections of bone marrow mononucleated cells for postradical prostatectomy erectile dysfunction: final results of the INSTIN clinical trial.
          Yiou R, Hamidou L, Birebent B, Bitari D, le Corvoisier P, Contremoulins I, et al. Eur Urol Focus. 2017;3:643–5.
        10. Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postradical Prostatectomy Erectile Dysfunction: An Open Dose-Escalation Pilot Study.
          Yiou R, Hamidou L, Birebent B, Bitari D, Lecorvoisier P, Contremoulins I, et al. Eur Urol. 2016;69:988–91.
        11. Engineering mesenchymal stem cells for regenerative medicine and drug delivery.
          Park JS, Suryaprakash S, Lao YH, Leong KW. Methods. 2015;84:3–16.
        12. Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury.
          Kendirci M, Trost L, Bakondi B, Whitney MJ, Hellstrom WJG, Spees JL. J Urol. 2010;184:1560–6.
        13. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts.
          Kim WS, Park BS, Sung JH, Yang JM, Park SB, Kwak SJ, et al. J Dermatol Sci. 2007;48:15–24.
        14. The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury.
          Bochinski D, Lin GT, Nunes L, Carrion R, Rahman N, Lin CS, et al. BJU Int. 2004;94:904–9.

Autografts: Platelet Rich Plasma (PRP/PRFM)

    1. 2021 Apr 16 – Effects of leukocyte- and platelet-rich plasma on tendon disorders based on in vitro and in vivo studies (Review)
      Xueli Liu, Rong Zhang, Bin Zhu, Yujie Li, et al. PMID: 33968170 PMCID: PMC8097231 DOI: 10.3892/etm.2021.10071
    2. 2021 Apr 8 – “Platelet-rich plasma holds promise in management of rheumatoid arthritis”-systematic review
      Girinivasan Chellamuthu, Sathish Muthu, Manish Khanna, Venus Khanna. PMID: 33834280 DOI: 10.1007/s00296-021-04849-9
    3. 2021 Mar 25 – Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature.
      Mercuri SR, Paolino G, Di Nicola MR, Vollono L. Medicina (Kaunas). 57(4):311. doi: 10.3390/medicina57040311.
    4. 2021 Mar 23 – Platelet-Rich Plasma Versus Corticosteroid Injection for Lumbar Spondylosis and Sacroiliac Arthropathy: A Systematic Review of Comparative Studies
      Jeremiah F Ling, Austin E Wininger, Takashi Hirase. PMID: 33898145 PMCID: PMC8061754 DOI: 10.7759/cureus.14062
    5. 2021 Mar 1 – Materials Selection for the Injection into Vaginal Wall for Treatment of Vaginal Atrophy.
      Zheng Z, Yin J, Cheng B, Huang W. Aesthetic Plast Surg. doi: 10.1007/s00266-020-02054-w.
    6. 2020 Sep 11 – Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis.
      Jia Zhu Tang, Ming Jun Nie, Jian Zhong Zhao, et al. J Orthop Surg Res. 2020 Sep 11;15(1):403. doi: 10.1186/s13018-020-01919-9.
    7. 2020 Aug 1 – Progress in the Use of Platelet-rich Plasma in Aesthetic and Medical Dermatology.
      Lin MY, Lin CS, Hu S, Chung WH. J Clin Aesthet Dermatol. 13(8):28-35. 
    8. 2020 Jun – A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women.
      Bruce AJ, Pincelli TP, Heckman MG, et al. Dermatol Surg. 46(6):826-832. doi: 10.1097/DSS.0000000000002168.
    9. 2020 Apr 13 – Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil(), Finasteride(), and Adult Stem Cell-Based Therapy.
      Gentile P, Garcovich S. Int J Mol Sci. 21(8):2702. doi: 10.3390/ijms21082702.
    10. 2020 Apr – The Physician’s Guide to Platelet-Rich Plasma in Dermatologic Surgery Part II: Clinical Evidence.
      Hausauer AK, Humphrey S. Dermatol Surg. 46(4):447-456. doi: 10.1097/DSS.0000000000002148.
    11. 2020 Mar – The Physician’s Guide to Platelet-Rich Plasma in Dermatologic Surgery Part I: Definitions, Mechanisms of Action, and Technical Specifications.
      Hausauer AK, Humphrey S. Dermatol Surg. 46(3):348-357. doi:
      10.1097/DSS.0000000000002147.
    12. 2020 Feb 28 – Platelet-rich plasma administration to the lower anterior vaginal wall to improve female sexuality satisfaction
      Gökmen Sukgen, Aşkı Ellibeş Kaya, Ebru Karagün, et al. Turk J Obstet Gynecol.  16(4): 228–234.
    13. 2019 Nov 19 – Use of Platelet-Rich Plasma for the Improvement of Pain and Function in Rotator Cuff Tears: A Systematic Review and Meta-analysis With Bias Assessment
      Xiao Chen, Ian A Jones, Ryan Togashi, Caron Park, C Thomas Vangsness Jr. PMID: 31743037 PMCID: PMC7234896 DOI: 10.1177/0363546519881423
    14. 2019 Sep 21 – Stromal vascular fraction-enriched platelet-rich plasma therapy reverses the effects of androgenetic alopecia.
      Butt G, Hussain I, Ahmad FJ, Choudhery MS. J Cosmet Dermatol. 19(5):1078-1085. doi: 10.1111/jocd.13149.
    15. 2019 Sep 14 – Assessment of autologous platelet-rich plasma as a local therapy for female sexual dysfunctionMohamed A Gaber, Shymaa A Shaltout. Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufia University, Menoufia, Egypt. Year: 2021 | Volume: 34 | Issue: 1 | Page: 61-65.
    16. 2019 Jun 15 – Platelet-rich plasma for facial rejuvenation: An early examination.
      Schoenberg E, Hattier G, Wang JV, Saedi N. Clin Dermatol. 38(2):251-253. doi: 10.1016/j.clindermatol.2019.06.003.
    17. 2019 Jun 11 – Platelet-Rich Plasma for Treating Androgenic Alopecia: A Systematic Review.
      Mao G, Zhang G, Fan W. Aesthetic Plast Surg. 43(5):1326-1336. doi: 10.1007/s00266-019-01391-9.
    18. 2019 Mar 26 – Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation
      Atefeh Samaie Nouroozi, Ashraf Alyasin, et. Asian Pac J Cancer Prev. 20(3): 817–823.
      doi: 10.31557/APJCP.2019.20.3.817
    19. 2019 Mar 2 – Platelet-rich plasma and treatment of erectile dysfunction: critical review of literature and global trends in platelet-rich plasma clinics.
      Scott S, Roberts M, Chung E. Sex Med Rev. 2019;7:306–12.
    20. 2019 Jan 11 – A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus.
      Goldstein AT, Mitchell L, Govind V, Heller D. J Am Acad Dermatol 80:1788–1789
    21. 2018 Oct 23 – Autologous pure platelet-rich plasma injections for facial skin rejuvenation: Biometric instrumental evaluations and patient-reported outcomes to support antiaging effects.
      Everts PA, Pinto PC, Girão L.  J Cosmet Dermatol. 18(4):985–995.
    22. 2018 Oct – Efficacy of injecting platelet concentrate combined with hyaluronic acid for the treatment of vulvovaginal atrophy in postmenopausal women with history of breast cancer: a phase 2 pilot study
      Barbara Hersant, Mounia SidAhmed-Mezi, Yazid Belkacemi, et al. Menopause. 25(10):1124-1130. doi: 10.1097/GME.0000000000001122.
    23. 2018 May 31 – Platelet rich plasma for photodamaged skin: a pilot study.
      Lee ZH, Sinno S, Poudrier G et al. J Cosmet Dermatol. 18(1):77–83.
    24. 2018 Jan 27 – Mechanical and controlled PRP injections in patients affected by androgenetic alopecia. 
      Gentile P, Garcovich S, Scioli MG et al. J Vis Exp. 131:56406.
    25. 2017 Dec 21 – Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions.
      Matz EL, Pearlman AM, Terlecki RP. Investig Clin Urol. 2018 Jan;59(1):61-65. doi: 10.4111/icu.2018.59.1.61.
    26. 2017 Dec 21 – The Efficacy of Platelet-Rich Plasma on Tendon and Ligament Healing: A Systematic Review and Meta-analysis With Bias Assessment
      Xiao Chen, Ian A Jones, Caron Park, C Thomas Vangsness Jr. PMID: 29268037 PMCID: PMC6339617 DOI: 10.1177/0363546517743746
    27. 2017 Oct 12 – O-shot: Platelet rich plasma in intimate female treatment.
      JB N J Women’s Health Care.
    28. 2017 Apr 28 – Rejuvenation using platelet-rich plasma and lipofilling for vaginal atrophy and lichen sclerosus.
      Kim SH, Park ES, Kim TH (2017) J Menopausal Med 23:63–68
    29. 2016 Jul 29 – Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. 
      Elnehrawy NY, Ibrahim ZA, Eltoukhy AM, Nagy HM. J Cosmet Dermatol. 16(1):103–111.
    30. 2014 – A Pilot Study of the Effect of Localized Injections of Autologous Platelet Rich Plasma (PRP) for the Treatment of Female Sexual Dysfunction
      Runels et al., J Women’s Health Care 2014, 3:4 DOI: 10.4172/2167-0420.1000169 
    31. 2014 Apr 29 – Platelet-rich therapies for musculoskeletal soft tissue injuriesVinícius Y Moraes 1, Mário Lenza, Marcel Jun Tamaoki, Flávio Faloppa, João Carlos Belloti. 2014(4):CD010071. doi: 10.1002/14651858.CD010071.pub3.
    32. 2013 Aug 16 – Optimization of platelet-rich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model.
      Wu Y-N, Wu C-C, Sheu M-T, et al. J Tissue Eng Regen Med. 2016;10:E294–304
    33. 2011 Nov 3 – Can platelet-rich plasma be used for skin rejuvenation? Evaluation of Effects of Platelet-rich Plasma on Human Dermal Fibroblast.
      Lee Y, Kim DH, Je YJ, Kim CD, Lee YH, Seo YJ, et al. Ann Dermatol. 2011;23:424–31.
    34. 2009 Oct – Platelet-rich plasma: current concepts and application in sports medicine.Hall MP, Band PA, Meislin RT, Jazrawi LM, Cardone DA. J Am Acad Orthop Surg. 2009;17:602–8
    35. Platelet-rich plasma and treatment of erectile dysfunction: critical review of literature and global trends in platelet-rich plasma clinics.
      Scott S, Roberts M, Chung E. Sex Med Rev. 2019;7:306–12.
    36. Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions.
      Matz EL, Pearlman AM, Terlecki RP. Investig Clin Urol. 2018;59:61–5.
    37. Optimization of platelet-rich plasma and its effects on the recovery of erectile function after bilateral cavernous nerve injury in a rat model.
      Wu Y-N, Wu C-C, Sheu M-T, Chen K-C, Ho H-O, Chiang H-S. J Tissue Eng Regen Med. 2016;10:E294–304.
    38. Platelet-rich plasma: quantitative assessment of growth factor levels and comparative analysis of activated and inactivated groups.
      Lee JW, Hyun Kwon O, Kim TK, Cho YK, Choi KY, Chung HY, et al. Arch Plast Surg. 2013;40:530–5.
    39. The neuroprotective effect of platelet-rich plasma on erectile function in bilateral cavernous nerve injury rat model.
      Wu CC, Wu YN, Ho HO, Chen KC, Sheu MT, Chiang HS. J Sex Med. 2012;9:2838–48.
    40. Can platelet-rich plasma be used for skin rejuvenation? Evaluation of Effects of Platelet-rich Plasma on Human Dermal Fibroblast.
      Lee Y, Kim DH, Je YJ, Kim CD, Lee YH, Seo YJ, et al. Ann Dermatol. 2011;23:424–31.
    41. Platelet-rich plasma: current concepts and application in sports medicine.
      Hall MP, Band PA, Meislin RT, Jazrawi LM, Cardone DA. J Am Acad Orthop Surg. 2009;17:602–8.
    42. The effect of platelet-rich plasma on cavernous nerve regeneration in a rat model.
      Ding XG, Li SW, Zheng XM, Hu LQ, Hu WL, Luo Y. Asian J Androl. 2009;11:215–21.

Shockwave Therapy (ECSWT, LiSWT, RPT)

  1. 2021 Mar 15 – Reviewing the evidence for shockwave- and cell-based regenerative therapies in the treatment of erectile dysfunction.
    Drury R, Natale C, Hellstrom WJG. Ther Adv Urol. 13:17562872211002059. doi: 10.1177/17562872211002059.
  2. 2020 Apr 2 – Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence.
    Long, CY., Lin, KL., Lee, YC. et al. Sci Rep 10, 5818 (2020). https://doi.org/10.1038/s41598-020-62471-4
  3. 2019 Dec – Meta-analysis of randomized controlled trials that assess the efficacy of low-intensity shockwave therapy for the treatment of erectile dysfunction.
    Campbell JD, Trock BJ, Oppenheim AR, et al. Ther Adv Urol. 2019;11:175628721983836
  4. 2019 Aug – Efficacy and safety of novel low-intensity pulsed ultrasound (LIPUS) in treating mild to moderate erectile dysfunction: a multicenter, randomized, double-blind, sham-controlled clinical study.
    Cui W, Li H, Guan R, et al. Transl Androl Urol. 2019;8:307–19
  5. 2019 Jul 17 – Are Sound Waves the Key to Better Orgasms?
    BY Dahlia Singer, Glamour
  6. 2019 Jan 21 – Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised controlled trials.
    Sokolakis I, Hatzichristodoulou G. Int J Impot Res. 2019;31:177–94.
  7. 2018 Feb 1 – Low-intensity shockwave therapy for erectile dysfunction: a randomized clinical trial comparing 2 treatment protocols and the impact of repeating treatment.
    Kalyvianakis D, Memmos E, Mykoniatis I, et al. J Sex Med. 2018;15:334–45.
  8. 2017 Dec 27 – Treatment of stress urinary incontinence with low-intensity extracorporeal shock wave therapy in a vaginal balloon dilation induced rat model
    Alex K. Wu, Xiaoyu Zhang, Jianw, et al. Transl Androl Urol . 7(Suppl 1):S7-S16. doi: 10.21037/tau.2017.12.36.
  9. 2017 Sept 27 – Low-intensity extracorporeal shock wave therapy for erectile dysfunction: a systematic review and meta-analysis.
    Man L, Li G. Urology. 2018;119:97–103.
  10. 2017 Aug 10 – Efficacy of low-intensity shock wave therapy for erectile dysfunction: a systematic review and meta-analysis.Angulo JC, Arance I, de Las Heras MM, et al. Actas Urol Esp. 2017;41:479–90.
  11. Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised controlled trials.
    Sokolakis I, Hatzichristodoulou G. Int J Impot Res. 2019;31:177–94.
  12. Meta-analysis of randomized controlled trials that assess the efficacy of low-intensity shockwave therapy for the treatment of erectile dysfunction.
    Campbell JD, Trock BJ, Oppenheim AR, Anusionwu I, Gor RA, Burnett AL. Ther Adv Urol. 2019;11:175628721983836 his recent meta-analysis rigorously investigated using LI-ESWT as a therapy for vasculogenic ED specifically. The meta-analysis showed statistically significant improvement in IIEF, along with an EHS ≥ 3.
  13. Efficacy and safety of novel low-intensity pulsed ultrasound (LIPUS) in treating mild to moderate erectile dysfunction: a multicenter, randomized, double-blind, sham-controlled clinical study.
    Cui W, Li H, Guan R, et al. Transl Androl Urol. 2019;8:307–19 This recent clinical study was the first to evaluate the efficacy of LIPUS as a therapeutic device for mild to moderate ED. The study had promising results with significantly higher IIEF-EF scores with the intervention compared to control.
  14. Low-intensity extracorporeal shock wave therapy for erectile dysfunction: a systematic review and meta-analysis.
    Man L, Li G. Urology. 2018;119:97–103.
  15. Low-intensity shockwave therapy for erectile dysfunction: a randomized clinical trial comparing 2 treatment protocols and the impact of repeating treatment.
    Kalyvianakis D, Memmos E, Mykoniatis I, Kapoteli P, Memmos D, Hatzichristou D. J Sex Med. 2018;15:334–45.
  16. Efficacy of low-intensity shock wave therapy for erectile dysfunction: a systematic review and meta-analysis.
    Angulo JC, Arance I, de Las Heras MM, Meilán E, Esquinas C, Andrés EM. Actas Urol Esp. 2017;41:479–90.
  17. Short-term efficacy and safety of low-intensity extracorporeal shock wave therapy in erectile dysfunction: a systematic review and meta-analysis.
    Zou Z-J, Tang L-Y, Liu Z-H, Liang J-Y, Zhang R-C, Wang Y-J, et al. Int Braz J Urol. 2017;43:805–21.
  18. Effects of low-intensity extracorporeal shockwave therapy on erectile dysfunction: a systematic review and meta-analysis.
    Clavijo RI, Kohn TP, Kohn JR, Ramasamy R. J Sex Med. 2017;14:27–35.
  19. Low-intensity extracorporeal shock wave treatment improves erectile function: a systematic review and meta-analysis.
    Lu Z, Lin G, Reed-Maldonado A, Wang C, Lee YC, Lue TF. Eur Urol. 2017;71:223–33.
  20. Low-energy shock wave therapy ameliorates erectile dysfunction in a pelvic neurovascular injuries rat model.
    Li H, Matheu MP, Sun F, Wang L, Sanford MT, Ning H, et al. J Sex Med. 2016;13:22–32.
  21. Low-intensity pulsed ultrasound improves erectile function in Streptozotocin-induced type I diabetic rats.
    Lei H, Xin H, Guan R, et al. Urology. 2015;86:1241.e11–8.
  22. Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia.
    Hanawa K, Ito K, Aizawa K, Shindo T, Nishimiya K, Hasebe Y, et al. PLoS One. 2014;9:e104863.
  23. Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction.
    Vardi Y, Appel B, Jacob G, Massarwi O, Gruenwald I. Eur Urol. 2010;58:243–8.
  24. Extracorporeal cardiac shock wave therapy: first experience in the everyday practice for treatment of chronic refractory angina pectoris.
    Khattab AA, Brodersen B, Schuermann-Kuchenbrandt D, Beurich H, Tölg R, Geist V, et al. Int J Cardiol. 2007;121:84–5
  25. Short-time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment.
    Gotte G, Amelio E, Russo S, Marlinghaus E, Musci G, Suzuki H. FEBS Lett. 2002;520:153–5.

Supplements and Hormones

        1. The daily therapy with L-arginine 2,500 mg and tadalafil 5 mg in combination and in monotherapy for the treatment of erectile dysfunction: a prospective, Randomized Multicentre Study.
          Gallo L, Pecoraro S, Sarnacchiaro P, Silvani M, Antonini G. Sex Med. 2020.
        2. Efficacy and safety of common ingredients in aphrodisiacs used for erectile dysfunction: a review.
          Srivatsav A, Balasubramanian A, Pathak UI, Rivera-Mirabal J, Thirumavalavan N, Hotaling JM, et al. Sex Med Rev. 2020;8:431–42.
        3. Efficacy and tolerability of sildenafil/l-arginine combination relative to sildenafil alone in patients with organic erectile dysfunction. Andrology.
          El-Wakeel LM, Fouad FA, Saleem MD, Saber-Khalaf M. 2020;8:143–7.
        4. An analysis of popular online erectile dysfunction supplements.
          Balasubramanian A, Thirumavalavan N, Srivatsav A, Yu J, Hotaling JM, Lipshultz LI, et al. J Sex Med. 2019;16:843–52.
        5. The potential role of arginine supplements on erectile dysfunction: a systemic review and meta-analysis.
          Chang Rhim H, Kim MS, Park YJ, Choi WS, Park HK, Kim HG, et al. J Sex Med. 2019;16:223–34.
        6. Daily oral L-arginine plus tadalafil in diabetic patients with erectile dysfunction: a double-blinded, randomized, controlled clinical trial.
          El Taieb M, Hegazy E, Ibrahim A. J Sex Med. 2019;16:1390–7

          • This recent study is among the first RCTs to evaluate a combination therapy of tadalafil and L-arginine for ED. The study found that the combination therapy increased IIEF-5 scores more than either tadalafil or L-arginine alone.
        7. Efficacy of a preprostatectomy multi-modal penile rehabilitation regimen on recovery of postoperative erectile function.
          Osadchiy V, Eleswarapu SV, Mills SA, Pollard ME, Reiter RE, Mills JN. Int J Impot Res. 2019;32:323–8.
        8. Oral L-citrulline and transresveratrol supplementation improves erectile function in men with phosphodiesterase 5 inhibitors: a randomized, double-blind, placebo-controlled crossover pilot study.
          Shirai M, Hiramatsu I, Aoki Y, Shimoyama H, Mizuno T, Nozaki T, et al. Sex Med. 2018;6:291–6.
        9. Herbal dietary supplements for erectile dysfunction: a systematic review and meta-analysis.
          Borrelli F, Colalto C, Delfino DV, Iriti M, Izzo AA. Drugs. 2018;78:643–73.
        10. Apricus Biosciences Receives Complete Response Letter from FDA for Vitaros (alprostadil, DDAIP.HCI)
          2018
        11. Levels of L-arginine and L-citrulline in patients with erectile dysfunction of different etiology.
          Barassi A, Corsi Romanelli MM, Pezzilli R, Damele CAL, Vaccalluzzo L, Goi G, et al. Andrology. 2017;5:256–61

          • This study showed decreases in L-citrulline and L-arginine among patients with ED, specifically with an arteriogenic etiology. The study suggests that oral supplementation may reduce ED in these patients.
        12. A urologist’s guide to ingredients found in top-selling nutraceuticals for men’s sexual health.
          Cui T, Kovell RC, Brooks DC, Terlecki RP. J Sex Med. 2015;12:2105–17.
        13. Oral L-citrulline supplementation improves erectile function and penile structure in castrated rats.
          Hotta Y, Shiota A, Kataoka T, Motonari M, Maeda Y, Morita M, et al. Int J Urol. 2014;21:608–12.
        14. Alprostadil for the treatment of impotence.
          Hanchanale V, Eardley I. Expert Opin Pharmacother. 2014;15:421–8.
        15. Erectile dysfunction: Alprostadil cream Evidence summary [ESNM50]
          NICE (National Institute for Health and Care Excellence, Guidance and Advice
        16. Oral l-citrulline supplementation improves erectile function in rats with acute arteriogenic erectile dysfunction.
          Shiota A, Hotta Y, Kataoka T, Morita M, Maeda Y, Kimura K. J Sex Med. 2013;10:2423–9.
        17. Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study.
          Choi YD, Park CW, Jang J, Kim SH, Jeon HY, Kim WG, et al. Int J Impot Res. 2013;25:45–50.
        18. Citrulline a more suitable substrate than arginine to restore no production and the microcirculation during endotoxemia.
          Wijnands KAP, Vink H, Briedé JJ, van Faassen EE, Lamers WH, Buurman WA, et al. PLoS One. 2012;7:e37439.
        19. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction.
          Cormio L, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, et al. Urology. 2011;77:119–22.
        20. Efficacy and safety of Oral combination of Yohimbine and L-arginine (SX) for the treatment of erectile dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial.
          Akhondzadeh S, Amiri A, Bagheri AH. Iran J Psychiatry. 2010;5:1–3.
        21. Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction.
          Asian J Androl. 2009;11:356–61.
        22. Long-term, multicenter study of the safety and efficacy of topical alprostadil cream in male patients with erectile dysfunction.
          Rooney M, Pfister W, Mahoney M, Nelson M, Yeager J, Steidle C. J Sex Med. 2009;6:520–34.
        23. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
          Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, et al. Br J Clin Pharmacol. 2008;65:51–9.
        24. Red ginseng for treating erectile dysfunction: a systematic review.
          Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Br J Clin Pharmacol. 2008;66:444–50.
        25. An integrated analysis of alprostadil topical cream for the treatment of erectile dysfunction in 1732 patients.
          Padma-Nathan H, Yeager JL. Urology. 2006;68:386–91.
        26. Almost all about citrulline in mammals. Amino Acids.
          Curis E, Nicolis I, Moinard C, Osowska S, Zerrouk N, Bénazeth S, et al. 2005;29:177–205.
        27. Determination of citrulline in watermelon rind.
          Rimando AM, Perkins-Veazie PM. J Chromatogr A. 2005;1078:196–200.
        28. Morris SM. Enzymes of arginine metabolism.
          J Nutr. 2004;134:2743S–7S.
        29. Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial.
          Guay AT, Spark RF, Jacobson J, Murray FT, Geisser ME. Int J Impot Res. 2002;14:25–31.
        30. Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction.
          Lebret T, Hervé JM, Gorny P, Worcel M, Botto H. Eur Urol. 2002;41:608–13.
        31. Erectile dysfunction after non-nerve sparing radical pelvic surgery. Therapeutical experience with sildenafil and L-arginine evaluated by buckling test.
          Mantovani F, Patelli E, Colombo F, Pozzoni F, Confalonieri S, Pisani E. Minerva Med. 2001;92:285–7
        32. Yohimbine: a clinical review.
          Tam SW, Worcel M, Wyllie M. Pharmacol Ther. 2001;91:215–43.
        33. Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study.
          Klotz T, Mathers MJ, Braun M, Bloch W, Engelmann U. Urol Int. 1999;63:220–3.
        34. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study.
          Chen J, Wollman Y, Chernichovsky T, Iaina A, Sofer M, Matzkin H. BJU Int. 1999;83:269–73.
        35. The relaxation effects of ginseng saponin in rabbit corporal smooth muscle: is it a nitric oxide donor?
          Kim HJ, Woo DS, Lee G, Kim JJ. Br J Urol. 1998;82:744–8.
        36. Yohimbine for erectile dysfunction: a systematic review and meta- analysis of randomized clinical trials.
          Ernst E, Pittler MH. J Urol. 1998;159:433–6.
        37. Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum.
          Chen X, Lee TJ. Br J Pharmacol. 1995;115:15–8.
        38. Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction.
          Zorgniotti AW, Lizza EF. Int J Impot Res. 1994;6:33–5 discussion 36.

Hyperbaric Oxygen

  1. 2019 May 13 – Potential of hyperbaric oxygen in urological diseases.
    Tanaka T, Minami A, Uchida J, Nakatani T. Int J Urol. 2019;26:860–7.
  2. 2019 Mar 23 – The impact of hyperbaric oxygen therapy on erectile functions and serum testosterone levels in patients with erectile dysfunction.
    Sen V, Sahin MO, Irer B, Koc E, Yildiz G. Aging Male. 2020;23:66–70.
  3. 2018 Aug 8 – The effect of hyperbaric oxygen therapy on erectile functions: a prospective clinical study.
    Sahin MO, Sen V, Eser E, Koc E, Gumus U, Karakuzu C, et al. Urol Int. 2018;101:206–11.
  4. 2018 May 18 – Hyperbaric oxygen can induce angiogenesis and recover erectile function.
    Hadanny A, Lang E, Copel L, Meir O, Bechor Y, Fishlev G, et al. Int J Impot Res. 2018;30:292–9
  5. 2017 Oct 13 – A double-blind, randomized trial on the efficacy and safety of hyperbaric oxygenation therapy in the preservation of erectile function after radical prostatectomy.
    Chiles KA, Staff I, Johnson-Arbor K, et al. J Urol. 2018;199:805–11.
  6. 2012 Mar – Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury.
    Lin K-C, Niu K-C, Tsai K-J, et al. J Trauma Acute Care Surg. 2012;72:650–9.
  7. 2010 Nov 26 – Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction.
    Yuan JB, Yang LY, Wang YH, et al. Int Urol Nephrol. 2011;43:755–61.
  8. 2008 Jan 11 – The effect of hyperbaric oxygen therapy on erectile function recovery in a rat cavernous nerve injury model.Müller A, Tal R, Donohue JF, et al. J Sex Med. 2008;5:562–70.
  9. The impact of hyperbaric oxygen therapy on erectile functions and serum testosterone levels in patients with erectile dysfunction.
    Sen V, Sahin MO, Irer B, Koc E, Yildiz G. Aging Male. 2020;23:66–70.
  10. Potential of hyperbaric oxygen in urological diseases.
    Tanaka T, Minami A, Uchida J, Nakatani T. Int J Urol. 2019;26:860–7.
  11. Hyperbaric oxygen can induce angiogenesis and recover erectile function.
    Hadanny A, Lang E, Copel L, Meir O, Bechor Y, Fishlev G, et al. Int J Impot Res. 2018;30:292–9
  12. This recent study was the first to investigate HBOT as a therapy for non-surgical ED. The study showed significant increases in IIEF scores, demonstrating improvement in erectile function. A subset of the experimental group also underwent dynamic contrast-enhanced MRI, demonstrating improvements in penile perfusion.
  13. The effect of hyperbaric oxygen therapy on erectile functions: a prospective clinical study.
    Sahin MO, Sen V, Eser E, Koc E, Gumus U, Karakuzu C, et al. Urol Int. 2018;101:206–11.
  14. A double-blind, randomized trial on the efficacy and safety of hyperbaric oxygenation therapy in the preservation of erectile function after radical prostatectomy.
    Chiles KA, Staff I, Johnson-Arbor K, Champagne A, McLaughlin T, Graydon RJ. J Urol. 2018;199:805–11.
  15. Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury.
    Lin K-C, Niu K-C, Tsai K-J, Kuo J-R, Wang L-C, Chio C-C, et al. J Trauma Acute Care Surg. 2012;72:650–9.
  16. Hyperbaric oxygen therapy for recovery of erectile function after posterior urethral reconstruction.
    Yuan JB, Yang LY, Wang YH, Ding T, Chen TD, Lu Q. Int Urol Nephrol. 2011;43:755–61.
  17. The effect of hyperbaric oxygen therapy on erectile function recovery in a rat cavernous nerve injury model.
    Müller A, Tal R, Donohue JF, Akin-Olugbade Y, Kobylarz K, Paduch D, et al. J Sex Med. 2008;5:562–70.

Regenerative Biologics

  1. 2021 Jan 6 – Utilization of Orthobiologics by Sports Medicine Physicians: A Survey-based Study
    Peter C Noback, Claire A Donnelley, Nicholas C Yeatts, et al. PMID: 33410651 PMCID: PMC7793331 DOI: 10.5435/JAAOSGlobal-D-20-00185
  2. 2021 Jan 6 – Erectile Dysfunction Treatment Using Stem Cells: A Review.
    Protogerou V, Chrysikos D, Karampelias V, et al. Medicines (Basel). 8(1):2. 
  3. 2020 – Umbilical cord-derived Wharton’s jelly for regenerative medicine applications
    Ashim Gupta, Saadiq F. El-Amin III, Howard J. Levy, et al. Journal of Orthopaedic Surgery and Research (2020) 15:49 https://doi.org/10.1186/s13018-020-1553-7
  4. 2020 Oct 19 – Intra-Articular Injection of Amniotic Membrane and Umbilical Cord Particulate for the Management of Moderate to Severe Knee Osteoarthritis
    Olivia G Mead, Leon P Mead. Orthop Res Rev. 12:161-170. doi: 10.2147/ORR.S272980.
  5. 2020 Sept 10 – MSC-based therapy in female pelvic floor disorders.
    Sima, Y., Chen, Y. Cell Biosci 10, 104 (2020). https://doi.org/10.1186/s13578-020-00466-4
  6. 2020 Jul – Nonoperative Applications of Placental Tissue Matrix in Orthopaedic Sports Injuries: A Review of Literature
    Assem A Sultan, Nicolas S Piuzzi, Michael A Mont. PMID: 30365472 DOI: 10.1097/JSM.0000000000000684.
  7. 2020 Jun – Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium.
    Narita K, Fukuoka H, Sekiyama T, Suga H, Harii K. Dermatol Surg. 46(6):819-825. doi: 10.1097/DSS.0000000000002128.
  8. 2020 May 18 – Current advances in stem cell-based therapies for hair regeneration.
    Yuan AR, Bian Q, Gao JQ. Eur J Pharmacol. 881:173197. doi: 10.1016/j.ejphar.2020.173197.
  9. 2020 Apr 17 – Stem cell applications in regenerative medicine for stress urinary incontinence: A review of effectiveness based on clinical trials.
    Barakat B, Franke K, Schakaki S, Hijazi S, Hasselhof V, Vögeli TA. Arab J Urol. 18(3):194-205. doi: 10.1080/2090598X.2020.1750864. PMID: 33029431; PMCID: PMC7473152.
  10. 2020 Mar 18 – The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study-6 Months Results.
    Protogerou V, Beshari SE, Michalopoulos E, et al. Medicines (Basel). 7(3):14. 
  11. 2020 Mar 16 – Novel Emerging Therapies for Erectile Dysfunction.
    Kim S, Cho MC, Cho SY, et al. World J Mens Health. 2021 Jan;39(1):48-64.
  12. 2020 Mar 5 – Autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study.
    Tsuboi R, Niiyama S, Irisawa R, et al. J Am Acad Dermatol. 83(1):109-116. doi: 10.1016/j.jaad.2020.02.033.
  13. 2020 Jan 21 – Current status and prospects in the treatment of erectile dysfunction by adipose-derived stem cells in the diabetic animal model.
    Yan H, Ding Y, Lu M. Sex Med Rev. 2020;8:486–91.
  14. 2019 Oct 6 – The good, bad, and the ugly of regenerative therapies for erectile dysfunction.
    Campbell JD, Milenkovic U, Usta MF, et al. Transl Androl Urol. 2020 Mar;9 (Suppl 2):S252-S261. 
  15. 2019 Jun 25 – Amniotic Allograft Implantation for Midface Aging Correction: A Retrospective Comparative Study with Platelet-Rich Plasma
    Alissa Daviscorresponding author and Adam Augenstein. Aesthetic Plast Surg. 2019; 43(5): 1345–1352. doi: 10.1007/s00266-019-01422-5
  16. 2019 Jun 10 – Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata.
    Barbulescu CC, Goldstein NB, Roop DR, Norris DA, Birlea SA. J Invest Dermatol. 140(1):29-37. doi: 10.1016/j.jid.2019.03.1142.
  17. 2019 Jun 19 – Effects of adipose and bone marrow-derived mesenchymal stem cells on vaginal atrophy in a rat menopause model.
    Kasap B, Kasap S, Vatansever S, Kendirci R, Yilmaz O, Calisir M, Edgunlu T, Akin MN. Gene 711:143937
  18. 2019 May 16 – Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development.
    Gentile P, Garcovich S. Cells. 8(5):466. doi: 10.3390/cells8050466.
  19. 2019 May 15 – Operative Applications of Placental Tissue Matrix in Orthopaedic Sports Injuries: A Review of the Literature
    Assem A Sultan, Linsen T Samuel, Alexander Roth, et al. Surg Technol Int. 34:397-402. PMID: 30472724
  20. 2019 Mar 5 – Administration of adipose derived mesenchymal stem cells and platelet lysate in erectile dysfunction: a single center pilot study.
    Protogerou V, Michalopoulos E, Mallis P, et al. Bioengineering. 2019;6.
  21. 2018 Aug 31 – Safety and potential therapeutic effect of two intracavernous autologous bone marrow derived Mesenchymal stem cells injections in diabetic patients with erectile dysfunction: an open label phase I clinical trial.
    Al Demour S, Jafar H, Adwan S, et al. Urol Int. 2018;101:358–65.
  22. 2018 Jun 27 – A 12-month follow-up after a single intracavernous injection of autologous adipose-derived regenerative cells in patients with erectile dysfunction following radical prostatectomy: an open-label phase I clinical trial.
    Haahr MK, Harken Jensen C, Toyserkani NM, et al. Urology. 2018;121:203.e6–203.e13.
  23. Safety and potential effect of a single intracavernous injection of autologous adipose-derived regenerative cells in patients with erectile dysfunction following radical prostatectomy: an open-label phase I clinical trial.
    Haahr MK, Jensen CH, Toyserkani NM, et al. EBioMedicine. 2016;5:204–10
  24. 2017 Apr 4 – The Placenta: Applications in Orthopaedic Sports Medicine
    James Alexander McIntyre, Ian A Jones, Alla Danilkovich, C Thomas Vangsness Jr. PMID: 28375638 DOI: 10.1177/036354651769768
  25. 2016 Jan 10 – The use of human adipose-derived stem cells in the treatment of physiological and pathological vulvar dystrophies.
    Giuseppina Onesti M, Carella S, Ceccarelli S, Marchese C, Scuderi N. Stem Cells Int 2016:256146
  26. 2015 Nov 19 Human Amniotic Membrane-Derived Products in Sports Medicine: Basic Science, Early Results, and Potential Clinical ApplicationsJonathan C Riboh, Bryan M Saltzman, Adam B Yanke, Brian J Cole. PMID: 26585668 DOI: 10.1177/0363546515612750

Regenerative Biologics

  1. 2021 Apr 1 – Vaginal Rejuvenation: A Retrospective Review of Lasers and Radiofrequency Devices.
    Juhász MLW, Korta DZ, Mesinkovska NA. Dermatol Surg. 47(4):489-494. doi: 10.1097/DSS.0000000000002845.
  2. 2021 Feb 22 – The Effect of Photobiomodulation on Human Mesenchymal Cells: A Literature Review.
    Pinto H, Goñi Oliver P, Sánchez-Vizcaíno Mengual E. Aesthetic Plast Surg. doi: 10.1007/s00266-021-02173-y.
  3. 2020 Dec 22 – Microneedling for the Treatment of Scars: An Update for Clinicians
    Margit L W Juhasz, Joel L Cohen. Clin Cosmet Investig Dermatol. 13:997-1003. doi: 10.2147/CCID.S267192.
  4. 2020 Dec 16 – Comparison of Fractional Micro-Plasma Radiofrequency and Fractional Microneedle Radiofrequency for the Treatment of Atrophic Acne Scars: A Pilot Randomized Split-Face Clinical Study in China
    Ting Lan, Li Tang, Aiai Xia, et al. Lasers Surg Med. doi: 10.1002/lsm.23369.
  5. 2020 Nov 11 – The use of vaginal lasers in the treatment of urinary incontinence and overactive bladder, systematic review.
    Alsulihem A, Corcos J. Int Urogynecol J. 32(3):553-572. doi: 10.1007/s00192-020-04548-2.
  6. 2020 Nov 7 – Biostimulative effect of laser on growth of mesenchymal stem/stromal cells in vitro
    Natalia Siedlecka, Kaja Mecinska-Jundzill, Ewelina Fierek, et al. Postepy Dermatol Alergol. 37(5):771-780. doi: 10.5114/ada.2020.100487.
  7. 2020 Oct 28 – Proposed mechanisms of low-level light therapy in the treatment of androgenetic alopecia.
    Guo Y, Qu Q, Chen J, Miao Y, Hu Z. Lasers Med Sci. doi: 10.1007/s10103-020-03159-z. PMID: 33111207.
  8. 2020 Oct 19 – Management and prevention of laser complications in aesthetic medicine: An analysis of the etiological factors
    Natalia G Kalashnikova, Mohammad Jafferany, Torello Lotti. Dermatol Ther. 34(1):e14373. doi: 10.1111/dth.14373.
  9. 2020 Oct 18 – Fractional CO2 Laser for Treatment of Vulvovaginal Atrophy: A Short Time Follow-up.
    Ghanbari Z, Sohbati S, Eftekhar T, et al. J Family Reprod Health. 14(2):68-73. doi: 10.18502/jfrh.v14i2.4347.
  10. 2020 Sept 29 – Microneedling in androgenetic alopecia; comparing two different depths of microneedles
    Gita Faghihi, Samin Nabavinejad, Fatemeh Mokhtari, et al. J Cosmet Dermatol. 20(4):1241-1247. doi: 10.1111/jocd.13714.
  11. 2019 Jul 17 – Histological Modifications of Postmenopausal Vaginal Mucosa after Regenerative Solid State Laser Treatment: A Multicenter Study
    Dodero et al. Int J Womens Health Wellness 2019, 5:099 DOI: 10.23937/2474-1353/1510099
  12. 2020 Jun 17 – A cost-effectiveness analysis of vaginal carbon dioxide laser therapy compared with standard medical therapies for genitourinary syndrome of menopause-associated dyspareunia.
    Wallace SL, St Martin B, Lee K, Sokol ER. Am J Obstet Gynecol. 223(6):890.e1-890.e12. doi: 10.1016/j.ajog.2020.06.032.
  13. 2020 May 1 – A Combination Approach to Treating Acne Scars in All Skin Types: Carbolic Chemical Reconstruction of Skin Scars, Blunt Bi-level Cannula Subcision, and Microneedling-A Case Series
    Peter P Rullan, Rachel Olson, Kachiu C Lee. J Clin Aesthet Dermatol. 13(5):19-23.
  14. 2019 Jun 17 – The Rationale for Photobiomodulation Therapy of Vaginal Tissue for Treatment of Genitourinary Syndrome of Menopause: An Analysis of Its Mechanism of Action, and Current Clinical Outcomes.
    Lanzafame RJ, de la Torre S, Leibaschoff GH. Photobiomodul Photomed Laser Surg. 37(7):395-407. doi: 10.1089/photob.2019.4618.
  15. 2019 Nov 1 – Noninvasive Vaginal Rejuvenation: Radiofrequency Devices.
    Hoss E, Kollipara R, Fabi S. Skinmed. 17(6):396-398.
  16. 2019 Jun 29 – Preliminary results of the use of scalp microneedling in different types of alopecia
    Michela Starace, Aurora Alessandrini, Nicolò Brandi, et al. J Cosmet Dermatol. 19(3):646-650. doi: 10.1111/jocd.13061.
  17. 2019 Jun 17 – The Rationale for Photobiomodulation Therapy of Vaginal Tissue for Treatment of Genitourinary Syndrome of Menopause: An Analysis of Its Mechanism of Action, and Current Clinical Outcomes.
    Lanzafame RJ, de la Torre S, Leibaschoff GH. Photobiomodul Photomed Laser Surg. 37(7):395-407. doi: 10.1089/photob.2019.4618.
  18. 2019 Jun 13 – Laser treatment of epidermal nevi: A multicenter retrospective study with long-term follow-up  Azzam Alkhalifah, Frederike Fransen, Florence Le Duff, et al. J Am Acad Dermatol. 83(6):1606-1615. doi: 10.1016/j.jaad.2019.06.013
  19. 2019 Feb 5 – Vaginal laser therapy for urinary incontinence and genitourinary syndrome of menopause : A review.
    Ratz C. Urologe A. 2019 Mar;58(3):284-290. doi: 10.1007/s00120-019-0861-1.
  20. 2018 Dec 31 – Genitourinary syndrome of menopause treatment using lasers and temperature-controlled radiofrequency.
    Wańczyk-Baszak J, Woźniak S, Milejski B, Paszkowski T. Prz Menopauzalny. 17(4):180-184. doi: 10.5114/pm.2018.81743.
  21. 2018 Feb 15 – Nonsurgical Vulvovaginal Rejuvenation With Radiofrequency and Laser Devices: A Literature Review and Comprehensive Update for Aesthetic Surgeons.
    Qureshi AA, Tenenbaum MM, Myckatyn TM. Aesthet Surg J. 38(3):302-311. doi: 10.1093/asj/sjx138.
  22. 2018 Feb – Solid State Vaginal Laser for the Treatment of Genitourinary Syndrome of Menopause: A Preliminary Report
    D. Dodero, F. Frascani, M. Angelucci, et al. DOI: 10.4236/ojog.2018.82015
  23. 2017 Dec 21 – Microneedling for the treatment of hair loss?
    R M Fertig, A C Gamret, J Cervantes, A Tosti. J Eur Acad Dermatol Venereol. 32(4):564-569. doi: 10.1111/jdv.14722.
  24. 2017 Dec – New therapeutic option in genitourinary syndrome of menopause: pilot study using microablative fractional radiofrequency.
    Kamilos MF, Borrelli CL. Einstein (Sao Paulo). 15(4):445-451. doi: 10.1590/S1679-45082017AO4051.
  25. 2017 Aug 2 – Microablative fractional CO2 laser for the genitourinary syndrome of menopause: power of 30 or 40 W?
    Pitsouni E, Grigoriadis T, Falagas M, Tsiveleka A, Salvatore S, Athanasiou S. Lasers Med Sci. 32(8):1865-1872. doi: 10.1007/s10103-017-2293-8.
  26. 2017 Feb 4 – Laser therapy for the restoration of vaginal function.
    Gambacciani M, Palacios S. Maturitas. 99:10-15. doi: 10.1016/j.maturitas.2017.01.012.
  27. 2014 Dec 16 – Sexual function after fractional microablative CO₂ laser in women with vulvovaginal atrophy.Salvatore S, Nappi RE, Parma M, et al. Climacteric. 18(2):219-25. doi: 10.3109/13697137.2014.975197.

Peptides, Hormones, and Supplements

  1. 2021 Feb 2 – Pharmacologic management of nocturnal polyuria: a contemporary assessment of efficacy, safety, and progress toward individualized treatment.
    Monaghan TF, Weiss JP, Everaert K, Wein AJ. Ther Adv Urol. 13:1756287220988438. doi: 10.1177/1756287220988438.
  2. 2020 Oct 2 – Prevention and treatment of cystitis during menopause: efficacy of a nutraceutical containing D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon and Lactobacillus acidophilus.
    Mainini G, Passaro M, Schiattarella A, et al. 19(3):130-134. doi: 10.5114/pm.2020.99567.
  3. 2020 Sep 21 –  Effect of Vitamin D Supplement on Vulvovaginal Atrophy of the Menopause.
    Kamronrithisorn T, Manonai J, Vallibhakara SA, et al. Nutrients. 12(9):2876. doi: 10.3390/nu12092876.
  4. 2020 Aug 12 – Effects of vaginal administration of conjugated estrogens tablet on sexual function in postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlled trial.
    Bumphenkiatikul T, Panyakhamlerd K, Chatsuwan T, et al. BMC Womens Health. 20(1):173. doi: 10.1186/s12905-020-01031-4.
  5. 2020 Jun 1 – The daily therapy with L-arginine 2,500 mg and tadalafil 5 mg in combination and in monotherapy for the treatment of erectile dysfunction: a prospective, Randomized Multicentre Study.
    Gallo L, Pecoraro S, Sarnacchiaro P, Silvani M, Antonini G. Sex Med. 2020.
  6. 2020 Mar 2 – Efficacy and safety of common ingredients in aphrodisiacs used for erectile dysfunction: a review.
    Srivatsav A, Balasubramanian A, Pathak UI, et al. Sex Med Rev. 2020;8:431–42. 
  7. 2019 Jul 2 – Efficacy and tolerability of sildenafil/l-arginine combination relative to sildenafil alone in patients with organic erectile dysfunction. Andrology.
    El-Wakeel LM, Fouad FA, Saleem MD, Saber-Khalaf M. 2020;8:143–7.
  8. 2018 Jul 3 – Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial.
    Golmakani N, Parnan Emamverdikhan A, Zarifian A, et al. Int Urogynecol J. 30(5):831-837. doi: 10.1007/s00192-018-3698-z.
  9. 2018 May 1 – Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms: A Randomized Clinical Trial.
    Mitchell CM, Reed SD, Diem S, et al. JAMA Intern Med. 178(5):681-690. doi: 10.1001/jamainternmed.2018.0116.
  10. 2017 Dec 1 – A Randomized, Multicenter, Double-Blind, Study to Evaluate the Safety and Efficacy of Estradiol Vaginal Cream 0.003% in Postmenopausal Women with Vaginal Dryness as the Most Bothersome Symptom.
    Archer DF, Kimble TD, Lin FDY, et al. J Womens Health (Larchmt). 27(3):231-237. doi: 10.1089/jwh.2017.6515.
  11. 2015 Nov 3 – A urologist’s guide to ingredients found in top-selling nutraceuticals for men’s sexual health.Cui T, Kovell RC, Brooks DC, Terlecki RP. J Sex Med. 2015;12:2105–17.