Frequently Asked Questions
1. Why should we trust you to deliver our order when other companies are unable to?
a. Dallas Regenerative Solutions is licensed by the State of Texas to distribute medical devices and has been in the business of helping practitioners implement regenerative procedures into their cash-pay practices for many years by sourcing devices from manufacturers from all over the world. We made a quick pivot to COVID-19 supplies when we saw the current supply chain was not equipped to handle the increasing demand.
Due to our longstanding relationships with overseas suppliers, logistics professionals, and domestic distribution solutions, we are able to quickly, efficiently, and affordably get these items into the hands of our medical professionals, first responders, and more where they are needed most.
2. How quickly can we receive our items once ordered?
a. Orders are processed and expected to ship within 7 days of PO submittal and can be shipped either by Air or Sea freight from overseas. We estimate that your order will arrive in 13-16 days when shipped by air and 18-25 days when shipped by sea.
3. What is included in the Unit Price of the order?
a. The Unit Price includes freight charges from overseas, import tariffs and other fees. Sales tax will be added to any orders placed in Texas unless Dallas Regenerative is provided with a sales tax exemption form.
b. Domestic shipping costs are added at the bottom and based off of the total order size.
4. The Dallas Regenerative Solutions quote states at the bottom: “Prices are accurate at time of publication, but are subject to change at any time, at the sole discretion of Dallas Regenerative Solutions, and without notice. Please reference your Purchase Order for the most current pricing.” Where does a PO fit into the ordering process? Are a Seller’s invoice and a PO different?
a. Once you submit your signed quote, it becomes a purchase order meaning that you’ve locked in your price for that item. If the price/pcs changes, which it does daily, Dallas Regenerative will honor the price on your purchase order regardless of whether it rises or falls. Dallas Regenerative will then provide a final invoice, incorporating any unaccounted-for sales taxes if applicable.
What are Exosomes
Exosomes are small structures secreted by most cell types in our bodies that facilitate important functions. Exosomes have the ability to travel between cells and deliver their healing properties, which include lipids, proteins, and nucleic acids.
How Do Exosomes Work:
They have the ability to send DNA, RNA, and proteins to other cells. In fact, Exosomes activate a bi-phasic response. This is an immediate reaction and lasts about 24 hours until the initial proteins have been assimilated. After that, the messenger RNA has been inserted into the targeted cells and the process becomes live which helps ‘reprogram’ the cell for repair.
Mesenchymal Stem Cell (MSC) Exosomes
Exosomes are extracellular vesicles ranging between 30-150 nm that are produced by virtually every cell type as a means of intercellular communication They contain proteins (growth factors), mRNA (blueprint for protein production) and micro RNA (on a switch for specific protein production), all contained within a membrane similar to their parent cells that protects exosomal proteins and RNA from degradation until they are delivered to the target cell.
MSC exosomes are very different than exosomes found in adult bone marrow, which has a preponderance of hematopoietic stem cell exosomes, or amniotic fluid, which has primarily maternal epithelial cell exosomes. The distinct ability of MSC exosomes to induce connective tissue synthesis may be the basis of many of the remarkable clinical benefits that have been observed with stem cell therapy.
As we age, the number and function of the MSCs in our tissues declines sharply. Aged autologous progenitor cells produce about 30% of the cytokines and significantly different miRNAs compared with perinatal MSCs. This substantial difference in secretome confers a significant advantage of perinatal MSC exosomes over exosomes from aged autologous or allogeneic progenitor cells.
How do I learn more?
Complete our Request More Information form to be contacted by one of our regenerative consultants or call 833.RGN.R84U / 833.746.7848.